Kinetic screening is a crucial aspect of the drug discovery process, from confirmation of binding in early discovery to fine-tuning of drug-like properties in pre-clinical development. Grating coupled interferometry (GCI), is a surface-based, label-free biosensing technique. When target molecules (e.g. proteins) are attached to the sensor surface, binding of analytes leads to an increase in surface mass and hence to a change in the refractive index within the evanescent field near the sensing surface. In GCI, refractive index changes on a sensor surface are measured as time-dependent phase-shift signals (interferometry).
In biopharmaceutical applications, GCI plays a pivotal role in characterizing molecular interactions, providing insights on kinetic profiles and binding affinity. The waveRAPID (Repeated Analyte Pulses of Increasing Duration) assay allows for an increase in throughput while reducing overall experimental time.
Palestrante
- Stoyan Milev - Application Scientist, Biophysical Characterization, Malvern Panalytical
Mais informações
Who should attend?
- Anyone interested in characterizing molecular interactions.
- Anyone working within drug discovery (e.g. HTS, Assay Dev, Hit Validation, Lead Optimization, Pre-clinical)
What will you learn?
- In this webinar you will learn an overview of the WAVE technology, key applications and how the use of waveRAPID can increase throughput and reduce overall experimental time.
Lab to Clinic Webinar Series
The development of successful pharmaceutical drugs is a long time-consuming and expensive process. Each stage of the development workflow has unique challenges and requirements, each with it’s own analytical and characterization needs.
In this 4-part webinar series, we will cover a range of topics within the pharmaceutical development process starting with candidate selection and screening for binding kinetics, moving on to screening and controlling for API polymorphs and finishing up with the development of nasal sprays, aerosols and inhalers for drug delivery.
Throughout this series, we will highlight how technical challenges can be overcome by utilizing the appropriate analytical tools.
Want to know more?
Register for free for any sessions in our webinar series - and keep an eye out for the recordings afterwards too!