Particle profiling and Raman chemical imaging for optimized product formulation

This webinar, presented by Renishaw plc and Malvern Panalytical, will discuss how particle size input parameters may influence domain size and distribution in final dosage forms.

Formulators aim to create solid dosage forms that meet their design criteria such as disintegration and dissolution, and physical characteristics such as friability and hardness. To accomplish these goals, it is essential to know the mechanisms that result in the physical arrangement of the active and excipient ingredients within the final product. For this, the particle size and shape distribution of the input materials are evaluated. However, these undergo several transformations during a tablet formulation process and therefore may be difficult to directly correlate to the design criteria. By analysing the domains formed in tabletting, a clearer understanding of the tablet properties may be found and any relationship linked to particle size established.

In this webinar, we will discuss the technologies used to measure particle size of powders and the domain size of tablets and how they may be used to inform tablet performance criteria.