| 00:00:00 | How Size Exclusion Chromatography can improve processes and quality in biopharmaceutical development |
| 00:01:17 | Outline |
| 00:02:20 | Life sciences |
| 00:02:59 | Life science market sector |
| 00:04:15 | Development pipeline |
| 00:05:23 | Desired information |
| 00:06:46 | Life science sample considerations |
| 00:08:09 | Overview of SEC |
| 00:09:09 | What Is Chromatography? |
| 00:10:18 | Size Exclusion Chromatography |
| 00:12:31 | The Separation Process |
| 00:15:24 | SEC road map |
| 00:17:03 | The Detectors |
| 00:18:52 | SEC in life science applications |
| 00:19:24 | SEC in life science applications |
| 00:21:44 | Why OMNISEC is perfect for life science samples |
| 00:22:42 | Sample types suitable for SEC |
| 00:25:07 | Life science applications |
| 00:26:51 | Proteasome 20S loaded with Cytochrome C |
| 00:28:49 | Stretched Protein vs. Globular Protein |
| 00:30:19 | Intrinsic Viscosity for Proteins |
| 00:31:22 | Antibody Conformational Analysis |
| 00:32:43 | Conformational Changes |
| 00:33:37 | Conformational Changes |
| 00:34:16 | Compositional Analysis |
| 00:35:23 | Compositional Analysis |
| 00:36:34 | PEGylated Proteins – Compositional Analysis |
| 00:37:14 | PEGylated Proteins – Compositional Analysis |
| 00:38:15 | Protein Detergent Complex (PDC) |
| 00:39:52 | Conclusions |
| 00:40:57 | Thank you for your attentionAny questions? |
| 00:45:13 | Contact Information |
Size Exclusion Chromatography (SEC) is a valuable technique for the analysis of macromolecules such as proteins, antibodies, and polysaccharides. Characterization of these materials is essential for many applications, ranging from pharmaceutical/biopharmaceutical manufacturing and development to drug delivery.
As such, SEC has become a fixture in research and QC labs to provide molecular weight, size, shape, purity, and additional information, allowing scientists to exert maximum control over their processes and improve product characteristics and quality.
This webinar will explore the molecular characterization information made available by SEC, and will include some relevant examples to touch upon how this data can assist throughout the drug development pipeline.
As such, SEC has become a fixture in research and QC labs to provide molecular weight, size, shape, purity, and additional information, allowing scientists to exert maximum control over their processes and improve product characteristics and quality.
This webinar will explore the molecular characterization information made available by SEC, and will include some relevant examples to touch upon how this data can assist throughout the drug development pipeline.