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The WAVEsystem, a Creoptix GCI Technology, puts a breakthrough level of binding kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The WAVE's exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D.
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The WAVEsystem combines the unrivaled high sensitivity of the GCI in the WAVEsystem with the WAVEcontrol software to give you superior data analysis and the WAVEchips, our no-clog microfluidic cartridges, to support a wide range of sample types and sizes. The WAVEsystem comes with a temperature-controlled autosampler that fits vials, two 96- or one 384-well plates for further ease of use. In its entirety, the system gives you an unparalleled platform for real-time label-free binding kinetics.
The WAVEsystem, a Creoptix GCI Technology, puts a breakthrough level of binding kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The WAVEsystem's exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. combines crude sample robustness, high sensitivity, and sophisticated software, to create a novel optical biosensor platform for real-time label-free binding kinetics. Engineered around innovative microfluidics and our proprietary Grating-Coupled Interferometry (GCI) technology, novel data from difficult samples is now possible for unsurpassed insight.
The WAVEsystem houses our patented Grating-Coupled Interferometry (GCI) technology. Together with a temperature-controlled autosampler that can handle 2x 48-vial racks, 96- or 384-well plates or combinations thereof, the WAVE offers the sensitivity to work with low immobilization levels and large ligand-to-analyte molecular weight (MW) ratios.
GCI differs from SPR in how the refractive index change is readout. In SPR, the surface plasmon is quickly attenuated and can pick up signals only from a few interactions. In GCI, each photon travels through the whole waveguide, and hence can pick up the signals from much more interactions, resulting in an intrinsically higher sensitivity.
In addition, the waveguide’s evanescent field penetrates less into the bulk, minimizing disturbances caused by bulk refractive index changes. Refractive index changes at the sensor surface are measured as time-dependent phase-shift signals. This allows for superior high signal-to-noise ratios, measurement of kinetics (ka, kd) and affinity (KD) from low pM to low mM, from signals below 1 pg/mm2 (equivalent to <1RU), for higher sensitivity and confident kinetic analysis.
Sensitivity is often limiting for accurate and reliable kinetic analysis of molecular interactions between large drug targets and small molecule inhibitors. Large target-to-analyte molecular weight ratios present a big challenge for traditional label-free quantification and can significantly impact data quality. The WAVEsystem is compatible with the high ligand-to-analyte molecular weight ratios, providing outstanding resolution and reliable kinetics with at low immobilization levels for target-to-analyte molecular weight ratios for up to >1000:1. The outcome is increased sensitivity to accurately measure low-potency small molecules or fragments, or targets with low activity.
GCI produces an evanescent field that penetrates less deep into the bulk than SPR, minimizing the disturbance caused by bulk refractive index changes.
This reduction in noise leads to superior signal-to-noise ratios.
Our patented GCI technology creates an interference readout in the time-domain and within the waveguide, instead of a space-domain signal being projected onto a CCD camera used with traditional waveguide interferometry methods. Measuring refractive index changes on the sensor surface as time-resolved phase-shift signals provides a more robust readout regardless of temperature drifts or vibrations, translating to superior resolution in signal and time.
The WAVEsystem puts a breakthrough level of kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The system’s exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D.
| Noise | WAVE: <0.01 pg/mm2 @ 1 Hz
WAVEdelta: <0.01 pg/mm2 @ 1 Hz |
|---|---|
| Drift | WAVE: <0.3 pg/mm2/min
WAVEdelta: <0.3 pg/mm2/min |
| Result output frequency | WAVE: 1 Hz, 10 Hz or 40 Hz
WAVEdelta: 1 Hz, 10 Hz or 40 Hz |
| Association Constant Range | WAVE: ka = 103 – 5x107 M-1 s–1 (small molecules), ka = 103 – 3x109 M-1 s–1 (large molecules)
WAVEdelta: ka = 103 – 5x107 M-1 s–1 (small molecules), ka = 103 – 3x109 M-1 s–1 (large molecules) |
| Dissociation Constant Range | WAVE: kd = 10–6 – 10 s–1
WAVEdelta: kd = 10–6 – 10 s–1 |
| Temperature range | WAVE: 15 °C – 40 °C
WAVEdelta: 4 °C – 45 °C (max 20 °C below ambient) |
| Molecular weight range | WAVE: No lower limit
WAVEdelta: No lower limit |
| waveRAPID® Functionality | WAVE: No
WAVEdelta: Yes |
| Flow Channels / Path | WAVE: 2, parallel
WAVEdelta: 4, parallel |
|---|---|
| Channel Referencing | WAVE: 1-4 and 4-1 or 2-3 and 3-2
WAVEdelta: Any combination of the 4 channels |
| Flow cell | WAVE: Sealed, disposable, integrated into disposable WAVEchip
WAVEdelta: Sealed, disposable, integrated into disposable WAVEchip |
| Flow rate range | WAVE: 1 – 400 µl/min
WAVEdelta: 1 – 400 µl/min |
| Crude Sample Robustness | WAVE: Yes
WAVEdelta: Yes |
| Sample capacity | WAVE: 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml)
WAVEdelta: 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml) |
|---|---|
| Buffer | WAVE: 1 buffer
WAVEdelta: Automatic switching between 4 buffers |
| Degasser | WAVE: Built-in
WAVEdelta: Built-in |
| Injection volume | WAVE: < 450 µl, 100 µl typical
WAVEdelta: < 450 µl, 100 µl typical |
| Sample volume required | WAVE: Injection volume plus 15-50 µl (application dependent)
WAVEdelta: Injection volume plus 15-50 µl (application dependent) |
| Sample storage temperature range | WAVE: Ambient or 4°C – 20°C regulated
WAVEdelta: Ambient or 4°C – 20°C regulated |
| Sample Recovery | WAVE: Yes
WAVEdelta: Yes |
| Automation | WAVE: 120h of unattended operation
WAVEdelta: 120h of unattended operation |
| Information provided | WAVE: Kinetic and affnity data (ka, kd, KD)
WAVEdelta: Kinetic and affnity data (ka, kd, KD) |
|---|---|
| Graph view | WAVE: Real-time curves, multiple curve overlays, fit, report point plots
WAVEdelta: Real-time curves, multiple curve overlays, fit, report point plots |
| Data Extraction | WAVE: Curves, ka, kd, KD tables, graphs, reports
WAVEdelta: Curves, ka, kd, KD tables, graphs, reports |
| Data Analysis | WAVE: Fully automated data evaluation
WAVEdelta: Fully automated data evaluation |
| Kinetic Models | WAVE: Predefined models including 1:1 interaction, mass transport, heterogenous ligand, conformational change and bivalent
WAVEdelta: Predefined models including 1:1 interaction, mass transport, heterogenous ligand, conformational change and bivalent |
| Direct Kinetics | WAVE: Yes
WAVEdelta: Yes |
No-clog microfluidic sensor chip for every need
Fast, intuitive, automated software
Carefree or basic support for high-quality kinetic data and unparalleled performance.
Version number: MAN0657-03-EN
Version number: MAN0656-03-EN
Version number:
WAVEcontrol v4.9.3
WAVEcontrol v4.9.1
WAVEcontrol v4.8.4
WAVEcontrol v4.8.3
WAVEcontrol v4.7.4
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans. When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide support for your business. We offer the following service options:
Carefree Program |
Basic program |
Ideal for the regular userKnow what you are up to and plan your maintenance budget ahead of time |
Ideal for the occasional userCall us when you need us the most for a PM visit or a repair |
Care for the first year of your WAVEsystem puts a breakthrough level of binding kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The WAVEsystem's exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. is on us, with a warranty period that covers travel, labor and parts costs for one (1) onsite preventive maintenance (PM) visit to be carried out within 12 months. Travel, labor and parts costs for unscheduled repairs are also included. The different support programs ensure the continuous, high performance operation of your WAVEsystem.
The WAVEsystem combines the unrivaled high sensitivity of the GCI in the WAVEsystem with the WAVEcontrol software to give you superior data analysis and the WAVEchips, our no-clog microfluidic cartridges, to support a wide range of sample types and sizes. The WAVEsystem comes with a temperature-controlled autosampler that fits vials, two 96- or one 384-well plates for further ease of use. In its entirety, the system gives you an unparalleled platform for real-time label-free binding kinetics.
The WAVEsystem, a Creoptix GCI Technology, puts a breakthrough level of binding kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The WAVEsystem's exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. combines crude sample robustness, high sensitivity, and sophisticated software, to create a novel optical biosensor platform for real-time label-free binding kinetics. Engineered around innovative microfluidics and our proprietary Grating-Coupled Interferometry (GCI) technology, novel data from difficult samples is now possible for unsurpassed insight.
The WAVEsystem houses our patented Grating-Coupled Interferometry (GCI) technology. Together with a temperature-controlled autosampler that can handle 2x 48-vial racks, 96- or 384-well plates or combinations thereof, the WAVE offers the sensitivity to work with low immobilization levels and large ligand-to-analyte molecular weight (MW) ratios.
GCI differs from SPR in how the refractive index change is readout. In SPR, the surface plasmon is quickly attenuated and can pick up signals only from a few interactions. In GCI, each photon travels through the whole waveguide, and hence can pick up the signals from much more interactions, resulting in an intrinsically higher sensitivity.
In addition, the waveguide’s evanescent field penetrates less into the bulk, minimizing disturbances caused by bulk refractive index changes. Refractive index changes at the sensor surface are measured as time-dependent phase-shift signals. This allows for superior high signal-to-noise ratios, measurement of kinetics (ka, kd) and affinity (KD) from low pM to low mM, from signals below 1 pg/mm2 (equivalent to <1RU), for higher sensitivity and confident kinetic analysis.
Sensitivity is often limiting for accurate and reliable kinetic analysis of molecular interactions between large drug targets and small molecule inhibitors. Large target-to-analyte molecular weight ratios present a big challenge for traditional label-free quantification and can significantly impact data quality. The WAVEsystem is compatible with the high ligand-to-analyte molecular weight ratios, providing outstanding resolution and reliable kinetics with at low immobilization levels for target-to-analyte molecular weight ratios for up to >1000:1. The outcome is increased sensitivity to accurately measure low-potency small molecules or fragments, or targets with low activity.
GCI produces an evanescent field that penetrates less deep into the bulk than SPR, minimizing the disturbance caused by bulk refractive index changes.
This reduction in noise leads to superior signal-to-noise ratios.
Our patented GCI technology creates an interference readout in the time-domain and within the waveguide, instead of a space-domain signal being projected onto a CCD camera used with traditional waveguide interferometry methods. Measuring refractive index changes on the sensor surface as time-resolved phase-shift signals provides a more robust readout regardless of temperature drifts or vibrations, translating to superior resolution in signal and time.
The WAVEsystem puts a breakthrough level of kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The system’s exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D.
| Noise | WAVE: <0.01 pg/mm2 @ 1 Hz
WAVEdelta: <0.01 pg/mm2 @ 1 Hz |
|---|---|
| Drift | WAVE: <0.3 pg/mm2/min
WAVEdelta: <0.3 pg/mm2/min |
| Result output frequency | WAVE: 1 Hz, 10 Hz or 40 Hz
WAVEdelta: 1 Hz, 10 Hz or 40 Hz |
| Association Constant Range | WAVE: ka = 103 – 5x107 M-1 s–1 (small molecules), ka = 103 – 3x109 M-1 s–1 (large molecules)
WAVEdelta: ka = 103 – 5x107 M-1 s–1 (small molecules), ka = 103 – 3x109 M-1 s–1 (large molecules) |
| Dissociation Constant Range | WAVE: kd = 10–6 – 10 s–1
WAVEdelta: kd = 10–6 – 10 s–1 |
| Temperature range | WAVE: 15 °C – 40 °C
WAVEdelta: 4 °C – 45 °C (max 20 °C below ambient) |
| Molecular weight range | WAVE: No lower limit
WAVEdelta: No lower limit |
| waveRAPID® Functionality | WAVE: No
WAVEdelta: Yes |
| Flow Channels / Path | WAVE: 2, parallel
WAVEdelta: 4, parallel |
|---|---|
| Channel Referencing | WAVE: 1-4 and 4-1 or 2-3 and 3-2
WAVEdelta: Any combination of the 4 channels |
| Flow cell | WAVE: Sealed, disposable, integrated into disposable WAVEchip
WAVEdelta: Sealed, disposable, integrated into disposable WAVEchip |
| Flow rate range | WAVE: 1 – 400 µl/min
WAVEdelta: 1 – 400 µl/min |
| Crude Sample Robustness | WAVE: Yes
WAVEdelta: Yes |
| Sample capacity | WAVE: 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml)
WAVEdelta: 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml) |
|---|---|
| Buffer | WAVE: 1 buffer
WAVEdelta: Automatic switching between 4 buffers |
| Degasser | WAVE: Built-in
WAVEdelta: Built-in |
| Injection volume | WAVE: < 450 µl, 100 µl typical
WAVEdelta: < 450 µl, 100 µl typical |
| Sample volume required | WAVE: Injection volume plus 15-50 µl (application dependent)
WAVEdelta: Injection volume plus 15-50 µl (application dependent) |
| Sample storage temperature range | WAVE: Ambient or 4°C – 20°C regulated
WAVEdelta: Ambient or 4°C – 20°C regulated |
| Sample Recovery | WAVE: Yes
WAVEdelta: Yes |
| Automation | WAVE: 120h of unattended operation
WAVEdelta: 120h of unattended operation |
| Information provided | WAVE: Kinetic and affnity data (ka, kd, KD)
WAVEdelta: Kinetic and affnity data (ka, kd, KD) |
|---|---|
| Graph view | WAVE: Real-time curves, multiple curve overlays, fit, report point plots
WAVEdelta: Real-time curves, multiple curve overlays, fit, report point plots |
| Data Extraction | WAVE: Curves, ka, kd, KD tables, graphs, reports
WAVEdelta: Curves, ka, kd, KD tables, graphs, reports |
| Data Analysis | WAVE: Fully automated data evaluation
WAVEdelta: Fully automated data evaluation |
| Kinetic Models | WAVE: Predefined models including 1:1 interaction, mass transport, heterogenous ligand, conformational change and bivalent
WAVEdelta: Predefined models including 1:1 interaction, mass transport, heterogenous ligand, conformational change and bivalent |
| Direct Kinetics | WAVE: Yes
WAVEdelta: Yes |
No-clog microfluidic sensor chip for every need
Fast, intuitive, automated software
Carefree or basic support for high-quality kinetic data and unparalleled performance.
Version number: MAN0657-03-EN
Version number: MAN0656-03-EN
Version number:
WAVEcontrol v4.9.3
WAVEcontrol v4.9.1
WAVEcontrol v4.8.4
WAVEcontrol v4.8.3
WAVEcontrol v4.7.4
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans. When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide support for your business. We offer the following service options:
Carefree Program |
Basic program |
Ideal for the regular userKnow what you are up to and plan your maintenance budget ahead of time |
Ideal for the occasional userCall us when you need us the most for a PM visit or a repair |
Care for the first year of your WAVEsystem puts a breakthrough level of binding kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The WAVEsystem's exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. is on us, with a warranty period that covers travel, labor and parts costs for one (1) onsite preventive maintenance (PM) visit to be carried out within 12 months. Travel, labor and parts costs for unscheduled repairs are also included. The different support programs ensure the continuous, high performance operation of your WAVEsystem.
Next-generation bioanalytical instrument with no-clog microfluidics and powerful software. Leading the way in GCI technology and real-time label-free binding kinetics.
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