Modules and detectors
OMNISEC REVEAL
An integrated multi-detector for advanced GPC/SEC measurements, incorporating refractive index, UV/Vis, light scattering and viscosity detectors.
- Premium advanced detection for GPC/SEC
- Fully integrated temperature-controlled detector module for improved detector stability and sample characterization
- More reliable measurements with market leading light scattering sensitivity
- Measure low concentration samples with a highly sensitive and stable refractive index detector
- Improved structural comparisons enabled with the unique mechanical auto balance of the differential viscometer
- See the full range of your samples' UV absorbance with the UV-PDA
OMNISEC REVEAL ULTRA
- The ultimate in advanced detection for UPLC/UHPLC and APC
- Optimized low volume system to maintain sample resolution
SEC-MALS 20 or 9
A powerful modular MALS detector for direct absolute molecular weight and size measurement, easy to combine with any existing GPC/SEC system.
- Multi-angle light scattering detector to measure absolute molecular weight and molecular size
- Increased confidence of measured data due to the vertical flow cell with radial optics – reduces noise at low angles, increasing data quality
- Vertical flow cell eliminates the need to regularly clean the system
- Use as the sole light scattering source on OMNISEC, or add as a powerful additional detector that compliments the RALS/LALS
OMNISEC RESOLVE
A combined pump, degasser, autosampler and column oven for mobile phase delivery and sample injection.
- Fully integrated into the OMNISEC software and hardware platform to offer a complete GPC/SEC solution from a single vendor
- Combined pump, degasser, autosampler and column oven in a single module
- Improved baseline stability with a Low pulsation pump
- Rapid solvent change overs with a low volume degasser giving maximum system productivity
- Temperature controlled Autosampler (4oC – 60oC) to protect thermolabile samples
OMNISEC Software
Designed to make GPC/SEC analysis easy, OMNISEC software guides setup, data acquisition and analysis in an intuitive workflow.
- A single user interface for all system setup, acquisition, and data processing
- 1-click from raw data to results
- Multi-Detection analysis to give Absolute Molecular weight, Intrinsic viscosity, concentration data and much more
- Conventional and Universal calibration methods to enable traditional retention volume-dependent techniques
- Measure conjugate and copolymer compositions using Compositional analysis – enables direct analysis of application-specific Drug Antibody Ratio (DAR), viral Titer and cp/vg ratio
- Fully automated system start-up, data acquisition and shutdown. All you need to do is insert your vials and press Start!
- 21 CFR part 11 compliant for peace of mind operation in a regulated environment
- Free software updates for the life of the instrument, no need to worry about expensive upgrade fees!
Key applications
OMNISEC can offer key information to a broad range of applications including:
Bioscience and Biopharmaceuticals
Quantify key metrics in stability profiling and biosimilarity. Accurately measure monomer, fragments and higher order aggregates independent of column retention volume for protein, viruses, VLP’s and more. Predict and understand immunogenicity and efficacy.
Application Note: Characterization of IgG monomers and their aggregates
Polymers, Plastics and Elastomers
Control strength, toughness, durability, brittleness, processability and more to optimize the product quality for the desired application. Control product quality by understanding the effects of changing raw material supply, synthesis or manufacturing processes.
Understand the impact of processing and reprocessing on key material properties using conventional and advanced technologies, such as additive manufacturing.
Gain a deeper insight into degradation products, additives or impurities present due to polymer recycling processes.
Application Note: GPC/SEC Analysis of Polymer Degradation
Gene therapy
Directly calculate critical to quality attributes for AAV samples. Percentage of full AAV, cp/vg, and viral titer are all easily accessible to enhance the process development and purification of new drug products.
Application Note: The importance of Multi-Detection SEC in gene therapy
Bioconjugation
Protein conjugation analysis allows accurate quantification of protein-polymer ratio, glycoprotein, and drug antibody ratios (DAR). Optimize the bioconjugation process to extend half-life, and cell permeability. Measure protein detergent ratios of isolated membrane proteins to improve the crystallization process.
Application Note: PEGylated proteins: Optimizing conjugation reactions using triple detection SEC
Paints and Inks
The effectiveness of printed polymers is linked to their macromolecular properties such as molecular weight and structural distributions. Understand the link between printing and the degradation of polymers is critical to ensure the efficacy of the printed pattern is not negatively impacted.
Webinar: Focus on Polymers - Characterization of Inks with GPC
Pharmaceutical
Polymeric excipient properties relate directly to clinical efficacy, safety, and quality of the product. Control the viscosity and molecular weight to ensure optimal performance or confirm the quality of sourced materials before they enter your production process.
Drug Delivery
Measure degradation and drug delivery rates. Drug release rates from medicines are directly linked to the structure of the polymeric material used to deliver them. Controlling these structures ensures the final payload is delivered to the correct location.
Food and Drinks
Control the mouthfeel and performance of food products by manipulating the molecular properties (Mw, IV) of the bulk material.
Optimize the depolymerization of native polysaccharides to produce specific thickening properties.
Monitoring degradation of polysaccharides due to processing or blending of different source materials.
Application Note: Monitoring degradation of sodium alginate using GPC/SEC
Accessories
OMNISEC
GPC and SEC Standards
A range of molecular weight standards for different applications of GPC/SEC
Support
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.
When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.
Help Desk
- Telephone and email support.
- Operators who take responsibility for your call and ensure your query is answered.
Training
- User training events
Software downloads
Malvern Panalytical's service options- choose the right plan for you:
Malvern Panalytical Platinum Plan
For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.
Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.
Malvern Panalytical Bronze Visit
For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.
| Platinum Plan | Gold Plan | Bronze Visit | |
|---|---|---|---|
| Annual PM/PV Test |
yes
|
yes
|
no
|
| Telephone / Email Support |
yes
|
yes
|
no
|
| Priority Response |
yes
|
yes
|
no
|
| Emergency Breakdown visits* |
yes
|
yes
|
no
|
| Parts Included |
yes
|
no
|
no
|
| Technical & Software Support |
yes
|
yes
|
yes
|
| IQ/OQ (Pharma)*** |
yes
|
yes
|
yes
|
*including labour & travel costs***available at an additional cost
