| 00:00:00 | A new approach to improving early characterization of therapeutic formulations - Viscosizer 200 |
| 00:00:55 | A new approach to improving early characterization of therapeutic formulations:Microcapillary flow and Taylor Dispersion Analysis |
| 00:01:25 | Introduction |
| 00:02:10 | Introduction |
| 00:02:13 | Introduction – Viscosizer 200 |
| 00:03:46 | Introduction – Viscosizer 200 |
| 00:04:31 | System Overview |
| 00:04:49 | Capillary |
| 00:05:12 | Measurements |
| 00:05:24 | Sizing |
| 00:06:13 | Size Measurements |
| 00:06:58 | Size Calculation |
| 00:07:30 | Taylor Dispersion Analysis |
| 00:08:00 | Taylor Dispersion Analysis |
| 00:08:21 | Measurements |
| 00:08:27 | Viscosity |
| 00:09:06 | Viscosity |
| 00:09:22 | Viscosity Measurements |
| 00:10:22 | Viscosity Calculations |
| 00:10:53 | Applications |
| 00:11:12 | Applications |
| 00:11:25 | Sizing of Small Molecules |
| 00:12:10 | Sizing of Small Molecules |
| 00:13:14 | Sizing proteins in the presence of large aggregates |
| 00:14:05 | Taylor Dispersion Analysis |
| 00:17:15 | Sizing Proteins in the Presence of Excipients |
| 00:17:34 | Sizing Proteins in the Presence of Excipients |
| 00:17:49 | Sizing Proteins in the Presence of Excipients |
| 00:18:12 | Sizing Proteins in the Presence of Excipients |
| 00:18:32 | Sizing Proteins in the Presence of Excipients |
| 00:19:04 | Applications |
| 00:19:13 | Comparative studies: monitoring protein change |
| 00:19:31 | Comparative studies: monitoring protein change |
| 00:20:13 | Applications |
| 00:20:30 | Biotherapeutic Viscosity |
| 00:21:34 | Effect of excipients on BSA formulation viscosity |
| 00:22:38 | Screening formulation viscosity |
| 00:23:20 | Viscosity measurements of non-UV active molecules |
| 00:24:36 | Summary |
| 00:25:32 | Thank You Any Questions? |
| 00:29:43 | Contact Information |
The accurate size measurement of both large and small therapeutic molecules within formulations has long been considered a challenge, complicated by the presence of excipient molecules and high background "noise". Malvern's Viscosizer 200 can see through these complications to measure only the molecules of interest, both accurately and repeatedly. During this webinar, data are presented to describe the analysis of molecules in formulations containing different excipients as well as the detection of conformational changes in proteins. In addition, the presentation covers the use of microcapillary viscometry to assess viscosity and potential deliverability issues which the technique is able to highlight in preformulation and early formulation development.