Recent developments in ITC instrumentation, namely MicroCal™ PEAQ-ITC and MicroCal PEAQ-ITC Automated, have led to an increase in the throughput and decrease in the protein consumption of the technique. In addition, recent methodological advancements have extended the affinity range that ITC can measure into the mM range. The combination of all these factors has made the technique ideal for fragment-based drug discovery campaigns (FBDD).
This work outlines the role of ITC instrumentation, in a fragment-based drug discovery program of Sprint Bioscience, to identify and optimize potential drug candidates that will inhibit the activity of Vps34. This class 3 phosphatidylinositol 3-kinase is central to autophagy and has been shown to play an important role in resistance to cancer drugs. As such it has been identified as a target for therapeutic intervention.
Please login or register for free to download the poster.
Recent developments in ITC instrumentation, namely MicroCal™ PEAQ-ITC and MicroCal PEAQ-ITC Automated, have led to an increase in the throughput and decrease in the protein consumption of the technique. In addition, recent methodological advancements have extended the affinity range that ITC can measure into the mM range. The combination of all these factors has made the technique ideal for fragment-based drug discovery campaigns (FBDD).
This work outlines the role of ITC instrumentation, in a fragment-based drug discovery program of Sprint Bioscience, to identify and optimize potential drug candidates that will inhibit the activity of Vps34. This class 3 phosphatidylinositol 3-kinase is central to autophagy and has been shown to play an important role in resistance to cancer drugs. As such it has been identified as a target for therapeutic intervention.
Please download the poster to read more.
