| 00:00:00 | Untitled |
| 00:00:47 | Introduction to the Viscosizer 200 |
| 00:01:03 | Agenda |
| 00:01:46 | 700 Malvern employees worldwide |
| 00:02:38 | Malvern’s commitment to biopharma |
| 00:03:39 | Overview of Biopharmaceutical Development Pipeline |
| 00:04:29 | Preformulation DevelopmentThe ideal application space for the Viscosizer 200 |
| 00:06:15 | Viscosizer 200 – System Overview |
| 00:07:30 | UV Area Imaging |
| 00:08:07 | How does the Viscosizer 200 measure sample viscosity? |
| 00:09:17 | How does the Viscosizer 200 measure size? |
| 00:09:57 | Specification and Application Overview |
| 00:11:38 | Viscosizer 200 |
| 00:11:55 | Applications Focus |
| 00:12:00 | Biotherapeutic Viscosity |
| 00:13:18 | Effect of excipients on BSA formulation viscosity |
| 00:14:26 | Screening formulation viscosity |
| 00:15:42 | Viscosity measurements of non-UV-active molecules |
| 00:16:57 | Flow Curves – “Apparent” Shear Thinning |
| 00:17:56 | Sizing of small molecules |
| 00:20:38 | Sizing proteins in the presence of large aggregates |
| 00:21:34 | Untitled |
| 00:24:23 | Concentration |
| 00:25:01 | Specification and Application Overview |
| 00:25:36 | Questions |
| 00:32:09 | Thank You |
This presentation introduces Taylor Dispersion Analysis and UV area detection in the Viscosizer 200 for automated, low volume measurements of relative viscosity, and for the sizing of proteins and small molecules, in excipient-laden formulations