By combining best-in-class resolution with the ability to analyze even the toughest samples, the Creoptix WAVE is revolutionizing the study of molecular interactions and changing the world of drug discovery.
Here we show selected examples of GCI applications in the field of low affinity small molecules and hit screening, including binding kinetics of small molecules as well as off-rate screening of crude reaction mixtures.
By combining best-in-class resolution with the ability to analyze even the toughest samples, the Creoptix WAVE is revolutionizing the study of molecular interactions and changing the world of drug discovery.
Engineered around grating-coupled interferometry (GCI), the WAVE offers superior data quality across the broadest range of compounds and samples types. The system can accurately characterize weak binder kinetics with off-rates well above 5 sec as well as high affinity antibodies. The WAVE's microfluidics sustain pure serum, cell supernatant, larger particles and even crude membrane and VLP extracts.
The WAVE can be used to analyze from low-molecular-mass drugs to multiprotein complexes and even larger particles like membrane extracts or virus-like particles. In addition, the system is capable of detecting interactions within a remarkably wide affinity range (from mM to pM).
Here we show selected examples of GCI applications in the field of low affinity small molecules and hit screening, including binding kinetics of small molecules as well as off-rate screening of crude reaction mixtures.
