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The new Zetasizer Ultra is our most advanced system for the measurement of particle and molecular size, particle charge and particle concentration, and represents the most intelligent and flexible instrument in the Zetasizer Advance range.
Our flagship model enjoys all the benefits afforded by ZS Xplorer software, in terms of ease of use, analysis speed and data confidence, and also offers two unique measurement capabilities: Multi-Angle Dynamic Light Scattering (MADLS) and particle concentration*, to offer even greater insight into your samples.
*Zetasizer Ultra Red Label only
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Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment
The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size. NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution for those critical measurements.
An extension to MADLS on the Zetasizer Ultra Red Label affords the ability to directly analyze particle concentration. The measurement of particle concentration is suitable for a wide range of materials, requires no or little dilution, and is quick to use – all of which make it ideal as a screening technique. This is a unique capability of the Zetasizer Ultra which can even be applied to samples such as viruses and virus-like particles (VLPs), which were previously very challenging to measure.
Key features of the Zetasizer Ultra include:
![[Mastersizer-Zetasizer-transparent-small-5.png] Mastersizer-Zetasizer-transparent-small-5.png](https://dam.malvernpanalytical.com/378eb0e0-f64c-4f9a-9243-b1f800a2242d/Mastersizer-Zetasizer-transparent-small-5_Original%20file.png)
| Upgrade your analysis!
Limited-time deal: Level up your new laser diffraction or light scattering purchase for free, OR trade in your old system for a discount. Find out more > |
| Zetasizer Ultra | Zetasizer Pro | Zetasizer Lab | |
|---|---|---|---|
| Size Measurement Principle | Non-Invasive Back Scatter (NIBS)
Dynamic Light Scattering Dynamic Light Scattering (90° and 13°) Multi-Angle Dynamic Light Scattering (MADLS®) | Non-Invasive Back Scatter (NIBS)
Dynamic Light Scattering | Classical 90° Dynamic Light Scattering |
| Zeta Measurement Principle | ELS with M3-PALS and Constant Current Zeta Mode | ELS with M3-PALS and Constant Current Zeta Mode | ELS with M3-PALS and Constant Current Zeta Mode |
| Molecular Weight and B22 | Static Light Scattering (90° and 173°) | Static Light Scattering (173°) | Static Light Scattering (90°) |
| Optical Filter Wheel (Fluorescence/DDLS) | Yes | Yes | No |
| Low Volume Disposable Sizing Cell with Extended Size Analysis Support | Yes | No | Yes |
| MADLS® (High Resolution DLS) | Yes | No | No |
| MADLS® - Particle Concentration/Titer | Yes2 | No | No |
| 21 CFR Part 11 compliant software | Optional via Omnitrust | Optional via Omnitrust | Optional via Omnitrust |
| Size | |||
| Range2 | 0.3 nm to 10 μm | 0.3 nm to 10 μm | 0.3 nm to 10 μm |
| Minimum Volume | 3 μL | 12 μL | 3 μL |
| Zeta potential | |||
| Size Range | 3.8 nm to 100 μm | 3.8 nm to 100 μm | 3.8 nm to 100 μm |
| Minimum Volume3 | 20 μL | 20 μL | 20 μL |
1 Red Label only
2 10 um by default. Option to extend for Zetasizer Lab and Zetasizer Ultra coming soon
3 Patented Diffusion Barrier method in capillary cell
The Zetasizer Ultra is suitable for a wide range of applications, including:
The strength of ceramics is linked to particle size, and the Zetasizer Ultra Blue Label is ideally placed to measure this. Al2O3 samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.
For protein researchers, early access to characterization data can be a challenge, due to low sample volumes. This is easily overcome using the Zetasizer Lab Red Label with the capillary cell to confirm that samples meet quality requirements and that production and purification processes are optimized.
The Zetasizer Ultra is used in many industries, including:
Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.
Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behaviour.
Customer story: Dolomite Microfluidics speeds and simplifies nanomaterial development workflow with Malvern Panalytical’s Zetasizer Ultra
| Measurement principle |
Non-Invasive Back Scatter (NIBS) Dynamic Light Scattering
Dynamic Light Scattering (90° and 13°)
Multi-Angle Dynamic Light Scattering (MADLS)
|
|---|---|
| Measurement angle |
173°, 13°, 90°
|
| Measurement range |
Diameter: 0.3 nm - 15 μm (2) (9)
|
| Minimum sample volume |
3 μL
|
| Concentration range |
Minimum sample concentration:
Blue Label: 0.2 mg/mL 15 kDa Protein
Red Label: 0.1 mg/mL 15 kDa Protein
MADLS:
0.1 mg/ml 15 kDa Protein
MADLS Particle Concentration Enabled?
Blue Label: No
Red Label: Yes
Maximum sample concentration(3):
40% w/v
|
| Measurement principle |
Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
|
|---|---|
| Size range |
3.8 nm – 100 μm
|
| Minimum sample volume |
20 μL (4)
|
| Concentration range |
Red Label: 1 mg/mL (5) to 40% w/v (6)
Blue Label: 10 mg/mL (5) to 40% w/v (6)
|
| Sample conductivity range |
Maximum: 260 mS/cm
|
| Molecular weight range | 300 Da – 20 mDa |
|---|---|
| Measurement principle |
Static Light Scattering with Debye Plot
|
| Accuracy |
+/- 10% typical
|
| Measurement principle |
Blue Label: N/A Red Label: MADLS - Particle Concentration (Mie) |
|---|---|
| Concentration range |
Blue Label: N/A Red Label: 1x108 to 1x1012 particles/mL |
| Calibration type |
Blue Label: N/A Red Label: Single point system calibration only |
| Detector |
Avalanche Photodiode
|
|---|---|
| Laser safety |
He-Ne (633 nm)
Blue label: 4 mW Max
Red label: 10 mW Max
|
| Temperature control range |
0°C to 120°C (7)
|
| Dimensions (W, D, H) |
322 mm x 565 mm x 245 mm
|
| Weight |
19 kg
|
| Power |
AC 100-240 V, 50-60 Hz, 4.0 A
|
| Power consumption |
Max 100 W, Typical 45 W
|
| Ambient conditions |
+10°C to +35°C, 35 - 80% RH (non-condensing)
|
| Interface |
USB 2.0 or higher
|
| Notes |
1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory.
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C
9 - Recommended upper size range for MADLS is 500nm diameter
|
|---|
Configure the Zetasizer Ultra for your applications and requirements with our range of configuration options:
Significantly improve your system utilization with the Sample Assistant – a new accessory for every Zetasizer Advance system. It frees the operator from manually changing samples.
The result? The same great data quality and versatility you expect from your Zetasizer Advance with even greater efficiency.
The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.
The MPT-3 is a cost-effective accessory for the Zetasizer Advance range, designed to automate your Zeta and/or Size vs. pH titrations, helping you understand how your materials behave as a function of pH.
The zeta potential and/or size of your materials with pH changes can be critical in understanding:
The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue.
The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell.
Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required.
The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range.
The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Advance system that measures zeta potential.
The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-3 autotitrator as well as batch measurements.
Our low volume disposable sizing cell (ZSU1002) design is unique in offering easy-fill, ultra-low volume size measurement in as little as 3 μL.
This quartz cuvette holds between 12 μL and 45 μL of sample and is used for size measurements. It is compatible with both aqueous and non-aqueous solvents and dispersants.
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.
When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.
For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.
Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.
For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.
| Platinum Plan | Gold Plan | Bronze Visit | |
|---|---|---|---|
| Annual PM/PV Test | yes | yes | no |
| Telephone / Email Support | yes | yes | no |
| Priority Response | yes | yes | no |
| Emergency Breakdown visits* | yes | yes | no |
| Parts Included | yes | no | no |
| Technical & Software Support | yes | yes | yes |
| IQ/OQ (Pharma)*** | yes | yes | yes |
*including labour & travel costs ***available at an additional cost
Unleash the potential of your data
Until now, instrument data has too often been stuck in manual records, spreadsheets or site-specific servers. By connecting your Zetasizer Ultra to our Smart Manager and continually analyzing instrument data in the cloud, you can unleash its full potential. This is just one of our digital solutions that are part of Malvern Panalytical's Smart Manager.
Get your new Zetasizer Ultra up and running faster when you choose to smart install.
With comprehensive resources to help you quickly and safely set-up and verify the performance of your new instrument, there’s no need to wait for an engineer to do it for you. What’s more, smart install presents a new training opportunity as you receive full access to exclusive training material.
How does it work?
When you follow the step-by-step video instructions, you could be up and running within 90 minutes of delivery of your new Zetasizer Ultra.
You don't need any specific skills or knowledge to perform a smart installation. Simply follow the instructions provided.
Everything needed to get started is provided with your new instrument – all you need is an internet connection to access the online training.
Exclusive e-learning content
Resources to get you up and running quickly and with confidence include:
Particle and molecular analysis with NIBS and MADLS in an easy to use, compact instrument. Advance your data capabilities with the market-leading successor to the Nano range.
