MicroCal PEAQ-DSC

MicroCal PEAQ-DSC instruments provide value to a wide range of applications, some of which are outlined below.

Protein Characterization 

MicroCal PEAQ-DSC is a fundamental tool for characterizing proteins. Key questions such as below can all be answered in simple DSC experiments.

• Is my protein folded?
• In what conditions is my protein stable?
• Is the protein multi domain?
• Does my protein bind a ligand or cofactor?

Webinar: The Power of Heat: Digging Deeper with Differential Scanning Calorimetry to Study Key Protein Characteristics 

Webinar: Value of DSC in characterization and optimization of protein stability as compared to other thermal stability assays

Liposomes

Liposomes are used as model membrane systems and as potential drug delivery systems. ‘Structure Activity Relationships’ (SAR) of membrane components and drug uptake into a liposomes can be investigated monitoring shifts in the phase transition temperatures and enthalpies measured by DSC. Indeed, any material that forms micelles or other macromolecular structures can be studied using the technique.

Webinar: Good practice for studying the stability of liposomes, their use as model systems and in drug delivery

Application note: Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes: The basics of liposome sample preparation and DSC studies