Overview
The software interface is logical and user friendly, even for a first time user.
Rebecca Dragovic — Teaching Fellow & Research Scientist, Nuffield Department of Women’s & Reproductive Health, University of Oxford
Features and benefits
Quick install & analysis
NanoSight Pro can be used by every user in every lab. Smart installation allows you to get up and running quickly. With minimum setup, easy operation and intuitive NS Xplorer software you can measure your samples in minutes.
Intelligent & automated
Powered by machine learning and intelligent features, NanoSight Pro automates processing and eliminates human error, delivering superior particle identification and precise particle tracking for the highest quality and reproducible data.
Highest resolution
The NanoSight Pro measures nanoscale particles in the range of 10 nm - 1000 nm including low scattering and biological particles. Particle–by–particle analysis assures high resolution size and concentration data with visual confirmation.
Power of fluorescence
In addition to light scatter, fluorescence signals can be detected from fluorescently tagged biologics or synthetic particles providing even greater insight into your sample. Interchangeable laser modules with the choice of four excitation wavelengths can be used along with the matching long pass filters for the optimum setup supported by analysis in flow for better sampling and tracking of even photobleaching samples.
The greater fluorescence sensitivity enables subpopulation identification including surface markers, internal cargo detection or depreciation of contaminants sensitivity.
What customers think
It is the easiest bit of equipment I have ever installed in the lab
Oliver Huseyin — Research scientist, MIP Diagnostics Limited
Connected world
Smart Manager
Unleash the potential of your data
Until now, instrument data has too often been stuck in manual records, spreadsheets or site-specific servers. By connecting your NanoSight Pro to our Smart Manager and continually analyzing instrument data in the cloud, you can unleash its full potential. This is just one of our digital solutions that are part of Malvern Panalytical's Smart Manager.
Key applications
The Malvern Panalytical NanoSight Pro can be used in many key applications, including:
-
- Extracellular Vesicles (EV)
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Whilst the research into the generation and functions of extracellular vesicles is still evolving, it is important to monitor and control their isolation and purification. NanoSight NTA provides quick and easy characterization of both the size and concentration of vesicles in aqueous buffers, giving confidence in the quality of the sample used in any downstream experiments, whilst the use of fluorescence can assist in elucidating the origin subpopulations of EVs.
- Virus and Vaccines
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Manufacture of vaccines requires controlled production processes to ensure that the materials can be appropriately dosed and recognized by the immune system. NTA assists in the optimization of manufacturing processes by ensuring the size distribution of the vaccine is maintained. As NTA is also able to count and size viruses, it can be used as a faster alternative to titer assays.
- Drug Delivery & Gene Therapy
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With drug delivery and gene therapy products, 70-150 nm is the typical size of particles required to ensure effective disease targeting in the clinical. NTA is ideally suited to study the size of these particles from early stage research through to candidate screening, formulation development and clinical batch monitoring whilst the concentration measurement allows for dose determination of the final product as well as for use in in vitro and in vivo assays.
- Biotherapeutics
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Temperature, pH change, agitation, shear and time all impact the stability of biotherapeutic proteins, causing denaturation and aggregation which can cause loss of efficacy and the potential for an unwanted immune response. NTA provides high resolution size distributions of sub-visible aggregates in a formulation for safety and quality assurance.
- Nanomaterials/colloids/toxicology
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As nanomaterials are incorporated in to everyday items, they are coming to the attention of regulatory bodies. There is a requirement to fully characterize these particles, their properties and contribution in the final product. NanoSight can provide a number-based concentration for these nanomaterials and high-resolution size distributions for those working at the nanoscale in industrial, environmental and toxicological fields.
- Ultrafine bubbles
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In recent years work on ultrafine bubbles has been gathering momentum for use in industrial cleaning and water treatment, agriculture and food, and medical applications amongst others. Their relatively low concentration and small size are a challenge for many traditional nanoparticle characterization techniques whereas NTA is particularly adept at the detection and analysis of these bubbles.
Webinar: Nanobubbles: What are they, what are their uses and how can I measure them?
Specification
General
| Technology | Nanoparticle Tracking Analysis |
|---|---|
| Size range (diameter)1 | 10 nm - 1000 nm
|
| Particle concentration2 | 106 to 109 particles / mL |
| Minimum sample volume | 250 μL |
| Advanced Concentration Algorithm | Concentration Upgrade |
System
| Product Compliance | Product Laser Class 1 (BS EN 60825-1:2014)
EMC Directive (EN IEC61326-1:2021) Low Voltage Directive (IEC 61010-1:2010 IEC 61010-1:2010/AMD 1:2016) |
|---|---|
| Camera | High sensitivity sCMOS (USB-3) |
| Laser information | Beam wavelength (maximum power output):
405 nm, max power <70 mW 488 nm, max power <55 mW (blue) 532 nm, max power <60 mW (green) 642 nm, max power <50 mW (red) |
| Temperature control range | 5 °C below ambient up to 70 °C |
| Temperature readout | Automatic |
| Syringe pump | Continuous sample flow with 1 mL syringes |
| Dimensions (W, D, H) | 250 x 350 x 340 mm |
| Weight of instrument | 11 kg |
| Weight of laser module | 1.6 kg |
| Power requirements | AC 110 – 240 V, 50-60 Hz, 4.0A |
| Ambient operating conditions | Up to 80% rH at 31 °C then decreasing linearly to 50% at 40 °C |
Additional options
| Fluorescence – automatic selection3 | For up to 5 filters |
|---|
1
Dependent on sample and instrument configuration
2
Sample dependent
3
Optional functionality. Long-pass filters available for each laser wavelength
Support
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.
When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.
Help Desk
- Telephone and email support .
- Operators who take responsibility for your call and ensure your query is answered.
Training
- User training events
Software downloads
Malvern Panalytical's service options- choose the right plan for you:
Malvern Panalytical Platinum Plan
For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.
Malvern Panalytical Gold Plan
Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.
Malvern Panalytical Bronze Visit
For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.
| Platinum Plan | Gold Plan | Bronze Visit | |
|---|---|---|---|
| Annual PM/PV Test |
yes
|
yes
|
no
|
| Telephone / Email Support |
yes
|
yes
|
no
|
| Priority Response |
yes
|
yes
|
no
|
| Emergency Breakdown visits* |
yes
|
yes
|
no
|
| Parts Included |
yes
|
no
|
no
|
| Technical & Software Support |
yes
|
yes
|
yes
|
| IQ/OQ (Pharma)*** |
yes
|
yes
|
yes
|
*including labour & travel costs ***available at an additional cost