In drug discovery, selection of compound hits with a potential for further development requires a full characterization of binding kinetics. Biophysical techniques such as isothermal titration calorimetry (ITC) and Grating-Coupled Interferometry (GCI) provide information on the global binding mechanisms of protein-protein or protein-ligand interaction, essential for hit characterization.
In the first part of the webinar, May Poh Lay, Senior Applications Specialist at Creoptix, will explain why the measurement of kinetics is critical when screening molecules, outlining the GCI technology behind WAVEsystem, how you can use the system, and the associated benefits.
In the second part, Dr. Cali Scholl, Application Engineer at TA Instruments, will talk about Isothermal Titration Calorimetry (ITC) and how binding interactions driven by enthalpic contributions are more specific, leading to less off-target binding resulting in fewer side effects.